Evidence map›Paper›PMID 42129847›Full record

ArticleCell communication and signaling : CCS2026

Valosin-containing protein is cargo in Amyloid Precursor Protein extracellular vesicles.

Yue Lu, Mohammad Abdullah, Liam R Healy, Tao Yin, Metin Yesiltepe, Luciano D'Adamio, Marc D Tambini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yue Lu *Department of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ, 07103, USA.
Mohammad Abdullah *Department of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ, 07103, USA.
Liam R HealyDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ, 07103, USA.
Tao YinDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ, 07103, USA.
Metin YesiltepeDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ, 07103, USA.
Luciano D'AdamioDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ, 07103, USA.
Marc D TambiniDepartment of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Brain Health Institute, Rutgers, The State University of New Jersey, 185 South Orange Ave, Newark, NJ, 07103, USA. mdt93@njms.rutgers.edu.

Funding

Studies of dementia pathogenesis in genetically faithful rat models of Familal Alzheimer diseaseR01AG063407 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI D'ADAMIO, LUCIANO · 2019 to 2023
$3.9M
Are mechanisms leading to FAD, SAD and age-associated cognitive decline similar?RF1AG064821 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI D'ADAMIO, LUCIANO · 2019 to 2019
$3.9M
Trem2-mediated microglia-neuronal axis in Alzheimer disease pathogenesisR01AG073182 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI D'ADAMIO, LUCIANO · 2021 to 2025
$3.9M
The Role of APP-metabolites on Extracellular Vesicle Cargo and FunctionR01AG091365 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MARC D TAMBINI · 2026 to 2026
$762k
Presenilin Knock-in Rat Model of NeurodegenerationR00AG065441 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI TAMBINI, MARC D · 2023 to 2025
$742k
NIA NIH HHS R00 AG065441NIA NIH HHS R00AG065441NIA NIH HHS R01 AG063407NIA NIH HHS R01AG063407NIA NIH HHS R01 AG073182NIA NIH HHS R01 AG091365NIA NIH HHS RF1 AG064821
6 · The paper itself

Abstract

The Amyloid Precursor Protein (APP), a genetic cause of Alzheimer's disease (AD), is a type-I transmembrane protein that is metabolized by proteolysis in the endolysomal system. APP and its metabolites are secreted by cells in extracellular vesicles (EVs). To study the function of APP-containing EVs, we isolated App-EVs from rat primary neuronal conditioned media and proteomic analysis identified the Valosin-containing protein (Vcp) as molecular cargo. Pharmacological modulation of Vcp activity was found to alter App processing and global EV secretion in rat primary neurons. AD-associated knock-in App mutations were found to alter the abundance of App-EVs and the trafficking of App metabolites within App-EVs, in a manner related to the epitopes generated by the nonamyloidogenic processing of App.

Indexed as

Adenosine TriphosphatasesAmyloid beta-Protein PrecursorCell Cycle ProteinsExtracellular VesiclesAnimalsCells, CulturedHumansNeuronsRatsValosin Containing ProteinAdenosine TriphosphatasesAmyloid beta-Protein PrecursorCell Cycle ProteinsValosin Containing ProteinVcp protein, rat

Identifiers

PMID42129847
PMCPMC13531989

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.