Evidence map›Paper›PMID 42129914›Full record

ArticleCritical care (London, England)2026

ExtracorporeaL life support and Modification Of Hemostasis: the ELMOH trial: hemostatic changes during the first 48 h of VV- and VA-ECMO: a prospective multicenter cohort study.

Harlinde Peperstraete, Korneel Vandewiele, Katrien M J Devreese, Paul Massion, Michaël Piagnerelli, Matthias Raes, Pieter Depuydt, Eric Hoste

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04912336 (Extra Corporeal Life Support and Modification of Hemostasis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04912336 completednot on this map

Extra Corporeal Life Support and Modification of Hemostasis

TypeobservationalSponsorUniversity Hospital, GhentRan2021 to 2024Enrolled43ConditionsBleeding Disorder, Extra Corporeal Life Support, ThrombosisArmsStandard coagulation profile, Specific coagulation tests, Bleeding Scores
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Harlinde PeperstraeteDepartment of Intensive Care Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, 9000, Belgium. harlinde.peperstraete@ugent.be.ORCID http://orcid.org/0000-0001-5435-1752
Korneel VandewieleGhent University, Faculty of medicine and health Sciences, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0003-2092-6321
Katrien M J DevreeseGhent University, Faculty of medicine and health Sciences, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-7559-2579
Paul MassionDepartment of Intensive Care Medicine, University Hospital of Liège, Avenue de l'Hôpital, 1, Liège, 4000, Belgium.
Michaël PiagnerelliDepartment of Intensive Care, CHU Charleroi-Chimay, Université libre de Bruxelles, Charleroi, 6042, Belgium.ORCID http://orcid.org/0000-0002-9201-827X
Matthias RaesDepartment of Intensive Care Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Jette, 1090, Belgium.ORCID http://orcid.org/0000-0002-6809-6921
Pieter DepuydtDepartment of Intensive Care Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, 9000, Belgium.ORCID http://orcid.org/0000-0001-5164-5376
Eric HosteDepartment of Intensive Care Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, 9000, Belgium.ORCID http://orcid.org/0000-0001-9301-8055

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnticoagulation during extracorporeal membrane oxygenation (ECMO) requires balancing thrombotic and bleeding risks, yet early coagulation dynamics may differ between venovenous (VV) and venoarterial (VA) support. This study prospectively characterized standard coagulation tests and viscoelastic profiles during the first 48 h of ECMO and related these to early bleeding and transfusion need.

methodsMulticenter, prospective cohort in four Belgian ICUs (03/2021-01/2023; NCT04912336). Adults initiated on VV- or VA-ECMO were enrolled immediately before cannulation and sampled at inclusion, + 2 h, + 24 h, and + 48 h. Laboratory tests (aPTT, PT/INR, fibrinogen, platelets, anti-Xa, D-dimer, AT), ROTEM, bleeding (BARC, GUSTO), and transfusions were recorded.

resultsForty-three patients were included (23 VV, 20 VA). At inclusion, platelet counts were higher in VV than in VA (median 292 vs. 145·10

conclusionsEarly hemostatic profiles differed markedly between patients requiring ECMO for circulatory failure and those supported for isolated respiratory failure. VA-ECMO showed lower platelet counts and a more hypocoagulable profile early after initiation that partially improved within 48 h, whereas VV-ECMO remained relatively hypercoagulable. These findings support the importance of individualized hemostatic monitoring and anticoagulation management.

Indexed as

Extracorporeal Membrane OxygenationHemostasisAdultBelgiumBlood Coagulation TestsCohort StudiesFemaleHemorrhageHumansMaleMiddle AgedProspective StudiesTime FactorsAnticoagulationAnti-factor XaBleeding and transfusionExtracorporeal membrane oxygenation (ECMO)HemostasisRotational thromboelastometry (ROTEM)ThrombocytopeniaUnfractionated heparinVenoarterial ECMO (VA-ECMO)Venovenous ECMO (VV-ECMO)

Identifiers

PMID42129914
PMCPMC13169905

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.