Evidence map›Paper›PMID 42129921›Full record

Trial reportPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026

Maternal characteristics associated with ovalbumin concentrations in breast milk.

Sophie A Hughes, Jessica R Metcalfe, Sharon L Perrella, Donna T Geddes, Debra J Palmer

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Maternal characteristics associated with ovalbumin concentrations in breast milk.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sophie A HughesThe Kids Research Institute Australia, The University of Western Australia, Nedlands, Western Australia, Australia.ORCID https://orcid.org/0009-0001-1570-9480
Jessica R MetcalfeThe Kids Research Institute Australia, The University of Western Australia, Nedlands, Western Australia, Australia.
Sharon L PerrellaSchool of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia.ORCID https://orcid.org/0000-0002-7727-7767
Donna T GeddesSchool of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia.
Debra J PalmerThe Kids Research Institute Australia, The University of Western Australia, Nedlands, Western Australia, Australia.ORCID https://orcid.org/0000-0003-2498-8343

Funding

Australian Government Research Training ProgramMedela AGNational Health and Medical Research Council ID 1046036National Health and Medical Research Council ID 2015724Stan Perron Charitable Foundation
6 · The paper itself

Abstract

backgroundBreast milk ovalbumin concentrations have been measured with considerable inter-individual variation. Body mass index (BMI) and gestational diabetes mellitus (GDM) in humans, and fish oil supplementation in pigs, have been associated with breast milk protein concentrations. This study aimed to identify whether breast milk ovalbumin concentrations are associated with these maternal characteristics.

methodsThis is a secondary analysis of data collected during a randomized trial. Breast milk ovalbumin concentrations were measured in 66 atopic women 2-6 h after consumption of one egg at 2, 4, and 6 weeks of lactation. Associations between ovalbumin concentrations and maternal characteristics (BMI, GDM and fish oil supplementation during pregnancy) were investigated.

resultsParticipants with GDM (n = 6) had higher ovalbumin concentrations at 2 weeks of lactation (median = 0.87 [IQR 0.27-2.17] ng/mL) compared to participants without GDM (n = 60, median = 0.15 [IQR 0.05-0.67] ng/mL; p = .03). Participants who consumed fish oil supplements during pregnancy (n = 16) had higher ovalbumin concentrations at 4 weeks (median = 0.39 [IQR 0.07-1.20] ng/mL) and 6 weeks (median = 0.29 [IQR 0.15-0.86] ng/mL) compared to those who did not (n = 50, median = 0.05 [IQR 0.05-0.44] ng/mL at 4 weeks, p = .01; and 0.05 [IQR 0.05-0.40] ng/mL at 6 weeks, p = .01). Pre-pregnancy BMI was not associated with ovalbumin concentrations.

conclusionsGDM and pregnancy fish oil supplementation were associated with higher breast milk ovalbumin concentrations. Future, larger studies should further investigate associations between these maternal characteristics and breast milk food protein concentrations.

Indexed as

Diabetes, GestationalMilk, HumanOvalbuminAdultAnimalsBody Mass IndexDietary SupplementsFemaleFish OilsHumansLactationPregnancyFish OilsOvalbuminbreast milkeggfish oilgestational diabetes mellitushuman milklactationmaternal characteristicsovalbumin

Identifiers

PMID42129921
PMCPMC13172436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.