Evidence map›Paper›PMID 42130621›Full record

ArticleFrontiers in oncology2026

Ultrasound localization microscopy for evaluation of therapeutic efficacy assessment after transarterial chemoembolization in hepatocellular carcinoma.

Ming-Yuan Wang, Li Lei, Xu Zhang, Fei Chen, Bao-Hua Li, Ya-Ning Yao, Long Deng, Jin-Duo Zhang, Yue-Zhen Sun, Jun-Qiang Lei and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ming-Yuan WangThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Li LeiThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Xu ZhangEndoscopic Diagnosis and Treatment Center, Gansu Provincial Hospital, Lanzhou, Gansu, China.
Fei ChenThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Bao-Hua LiThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Ya-Ning YaoThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Long DengThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Jin-Duo ZhangThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Yue-Zhen SunTianshui Disease Prevention and Control Center, Tianshui, Gansu, China.
Jun-Qiang LeiThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.
Shunlin GuoThe First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The timely and precise evaluation of the efficacy of Transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients facilitates post preventive and therapeutic therapy. This study aimed to demonstrate the significance of ultrasound localization microscopy (ULM) assessment of TACE. Methods: A total of 85 HCC patients underwent initial TACE were retrospectively analyzed. The ULM system automatically calculated relevant metrics, including vessel ratio, mean velocity, and perfusion index. A combined evaluation model was constructed by ULM parameters alongside routine laboratory indicators (AFP, WBC, RBC, ALP) selected via Random Forest and Logistic algorithm. Results: The combined model achieved an Area Under the Curve (AUC) of 0.915 in assessing TACE efficacy. The model demonstrated excellent calibration with a mean absolute error of 0.076 in clinic decision probabilities. Conclusion: ULM effectively reflects changes in the tumor vasculature in patients with HCC after TACE. Combining with WBC, RBC, ALP, and elevated AFP levels could improve evaluation performance.

Indexed as

clinical prediction modelhepatocellular carcinomamultimodal imagingtransarterial chemoembolizationultrasound localization microscopy

Identifiers

PMID42130621
PMCPMC13160713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.