ArticleFrontiers in endocrinology2026
Disrupted fluid homeostasis in patients with post-Covid-19 syndrome - a case series.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The post-covid-syndrome (PCS) is characterized by severe persisting fatigue and other long haul symptoms following COVID-19 infection. Disease-driving mechanisms are elusive, biomarkers are missing, treatment options few, and yet millions of people worldwide are affected. We hypothesized that the common complaint of polydipsia/polyuria and its attendant effect on osmolality can be quantified and identified as an unrecognized clinical feature of the PCS. We conducted a clinical case-series of 10 consecutive patients with PCS (5 females, 5 males; mean age 44 ± 14 y) who completed questionnaires covering health status, quality-of-life and post-covid symptoms. Detailed anamnestic work-up and clinical assessment were performed, and serum and urine osmolality (S-osm, U-osm) were determined after overnight fasting and fluid deprivation. Polydipsia and/or polyuria were reported by 7 patients, and measures of osmolality were abnormal in all 10 individuals. S-osm was above the reference range (285-292 mOsm/kg) in 9/10 patients (mean 298 ± 4), and U-osm was below the reference (>750 mOsm/kg) in 7/10 patients (mean 707 ± 149). The combination of high serum and low urine osmolality (n=6) was associated with poorer health status, when compared to single abnormality only (n=4). Signs of connective tissue disorders were common among participants, as were previous head-and-neck traumas and activities associated with myofascial distension. Data from this uncontrolled limited sized case series suggests disrupted fluid homeostasis as an unrecognized clinical feature of the PCS. The objective findings of high serum and low urine osmolality are candidates for diagnostic biomarkers as well as potential therapeutic targets and outcome measures.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.