ArticleRSC advances2026
Biodegradable cross-linked flavone networks featuring either ester or carbamate linkages for controlled delivery of anti-cancer agents.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Flavonoids show broad preclinical anticancer activity, but their translation to the clinic is limited by poor aqueous solubility, rapid metabolism and limited systemic exposure after conventional administration. Here, the flavonoids quercetin, luteolin and apigenin were exploited as multifunctional building blocks to generate insoluble cross-linked flavonoid networks containing either ester (1-3) or carbamate (4-6) linkages, intended as degradable local depot matrices. Network formation was confirmed by FTIR and thermal analysis, and flavonoid loading was quantified by exhaustive degradation (pH 2.0, 60 °C), giving loadings of 28-36 wt/wt% (esters) and 32-44 wt/wt% (carbamates). Release of parent flavonoids was quantified by HPLC under aqueous conditions (PBS, 37 °C) at pH 7.4, 6.5 and 5.0. Ester networks showed comparatively higher baseline release at pH 7.4, whereas carbamate networks exhibited stronger pH-responsiveness (
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