ArticleFrontiers in public health2026
Association of heavy metal mixtures with liver function biomarkers: multi-model analysis identifies cadmium as the primary driver.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Associations Between Hair Heavy Metal Concentrations and Frailty in Mexican Adults: a Cross-Sectional Study.Research square · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Evidence regarding the hepatotoxic effects of co-exposure to multiple heavy metals in the general middle-aged and older adults population remains limited. This study aimed to investigate the association between heavy metal mixtures and liver function in the population of Northwest China, with key findings supported using an animal model. Methods: We conducted a cross-sectional study involving 451 participants from the Dongdagou Xinglong cohort. Concentrations of heavy metals and liver function indices were measured. Multiple linear regression, Bayesian kernel machine regression (BKMR), weighted quantile sum (WQS), and quantile-based g-computation (Qgcomp) regression were employed to evaluate the combined effects of co-exposure to multiple heavy metals on liver function. A sub-chronic cadmium (Cd) exposure rat model was further established to validate population-based findings. Results: Multiple linear regression analysis revealed that blood Cd was positively correlated with GGT (β = 0.236), TBA (β = 0.162), ALT (β = 0.142) and AST (β = 0.114), while negatively correlated with DBil (β = -0.207), TBil (β = -0.166) and IBil (β = -0.157) (all Conclusions: Overall, our study shows that co-exposure to heavy metals is associated with liver function biomarkers in middle-aged and older adults, with Cd identified as the predominant factor associated with liver function biomarkers.
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