ArticleFrontiers in public health2026
Dopamine system as a mediator between psychological symptoms and relapse tendency: a cross-sectional study in women undergoing compulsory rehabilitation in Zhengzhou, China.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To examine whether psychological symptoms influence relapse propensity among individuals with drug dependence through the dopamine (DA) system, after controlling for confounders such as age. Ninety Women Individuals in Compulsory Drug Rehabilitation, aged 18-60 years, were enrolled. Key measures included psychological status [assessed via the Montreal Cognitive Assessment (MoCA), Self-rating Depression Scale (SDS), Symptom Checklist-90 (SCL-90), and Pittsburgh Sleep Quality Index (PSQI)]; physiological indicators [blood concentrations of serotonin (5-HT), interleukin-6 (IL-6), gamma-aminobutyric acid (GABA), and dopamine (DA)]; and socio-demographic and drug-use characteristics (age, education, marital status, years of drug use, etc.). Relapse propensity was quantified using a Relapse Propensity Scale score. Data analysis included Pearson correlation, stepwise multiple linear regression, and mediation analysis using the bootstrap method (PROCESS Model 4). Bivariate analysis revealed that relapse propensity was significantly correlated with age (
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