Evidence map›Paper›PMID 42131350›Full record

ReviewFrontiers in immunology2026

Contribution of immune cells and cytokines to radiation-induced injury: the key roles and potential targets.

Yanan Wu, Yuanjing Tian, YingYing Zhang, Pingping Hu, Lili Qiao, Guodong Deng, Ning Liang, Yan Zhang, Jiandong Zhang

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanan WuDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
Yuanjing TianDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
YingYing ZhangDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
Pingping HuDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
Lili QiaoDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
Guodong DengDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
Ning LiangDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
Yan ZhangDepartment of Diagnostics, Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Jiandong ZhangDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the useful applications of ionizing radiation in daily life, the heightened risks of radiation-induced injury have emerged as a significant challenge. Immune cells and the associated cytokines play crucial roles in orchestrating the inflammatory and repair processes that follow radiation exposure. These immune responses contribute to both the beneficial and detrimental outcomes of radiotherapy. Cytokines, in particular, regulate the recruitment and activation of immune cells, thereby influencing the extent and nature of tissue damage. By understanding the mechanisms underlying the interactions between immune cells and cytokines in radiation-induced injury, we can identify potential targets for therapeutic interventions. This article provides insights into the mechanisms underlying radiation-induced injury and highlights opportunities for enhancing the efficacy and safety of radiotherapy through immune-based interventions.

Indexed as

CytokinesRadiation InjuriesAnimalsHumansImmunomodulationCytokinescytokinesimmune cellsimmunomodulationinjuryradiation

Identifiers

PMID42131350
PMCPMC13160770

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.