ReviewReproductive medicine and biology
Reversibility of Spermatogonial Stem Cell Injury After Single Acute Scrotal Hyperthermia in Mouse and Rat Models: A Systematic Review.
Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Acute scrotal hyperthermia is a recognized spermatogenesis stressor, but recovery of spermatogonial stem cells after a single mild heat exposure remains unclear, particularly over cycle-relevant timeframes. This systematic review evaluates the in vivo local scrotal hyperthermia across at least one full spermatogenic cycle. Methods: A PICO-driven search identified 18 mouse and rat studies using a single scrotal heating exposure. Outcomes were synthesized thematically across structural, cellular, endocrine/apoptotic, and sperm domains. Results: Injury patterns were graded and temperature- and species-dependent, with more consistent abnormalities at 43°C and milder effects in rats than in mice. Structural endpoints often remained abnormal at the longest follow-up, and architectural repair did not reliably achieve functional recovery. Mouse stereology at 43°C indicated long-term SSC and germ-cell depletion, with Leydig-cell and partial Sertoli-cell losses; rat stereology was sparse and absent at 42°C. Testosterone responses were heterogeneous, whereas tubular apoptosis was more consistently elevated in mice at 43°C. Sperm concentration/count declined where assessed, with more frequent impairments of motility and other quality indices, including DNA integrity, at 43°C. Conclusion: Recovery was often incomplete and endpoint-specific, with impairment more consistently detected at 43°C, particularly in mice. Future studies require standardized thermal dosing, transparent bias-mitigation, and SSC/niche-resolved functional assays.
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