ReviewJournal of the American Heart Association2026
Optimal Exercise Modalities and Dosages for Blood Pressure Reduction in Adults With Prehypertension and Established Hypertension: A Network Meta-Analysis and Dose-Response Relationship Study.
Review in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise interventions can effectively reduce blood pressure (BP), but the optimal exercise modality and dose remain unclear. This study aimed to compare the effects of different exercise modalities and doses on systolic and diastolic BP using Bayesian network meta-analysis and dose-response modeling. Randomized controlled trials published up to April 2025 were searched, and a total of 105 randomized controlled trials were included. A random-effects model was applied to conduct both the network meta-analysis and dose-response analysis. Combined training and high-intensity interval training produced the most significant reductions in BP. Combined training reduced systolic BP by -12.05 mm Hg (95% CrI, -15.08 to -9.05) and diastolic BP by -6.20 mm Hg (95% CrI, -7.79 to -4.62), while high-intensity interval training reduced systolic BP by -10.97 mm Hg (95% CrI, -14.97 to -6.95) and diasatolic BP by -6.42 mm Hg (95% CrI, -8.68 to -4.16). Yoga and tai chi had moderate effects, whereas aerobic exercise, isometric exercise training, and resistance training showed relatively weaker effects. Dose-response analysis revealed a nonlinear U-shaped relationship, with the greatest benefit observed at ≈830 metabolic equivalents/min per wk, and the optimal doses varied by exercise modality. All exercise modalities can significantly reduce BP levels in individuals with prehypertension and established hypertension, and there is a nonlinear dose-response relationship between exercise volume and BP levels.
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