Evidence map›Paper›PMID 42132713›Full record

ArticleJACC. Advances2026

Bridging the Gap Between Genetic Cardiomyopathies and Pregnancy.

Karen Flores Rosario, Merna Hussien, Phoenix Grover, Courtlyn Witte, Richa Agarwal, Jenna Skowronski, Johanna Quist-Nelson, Michelle M Kittleson, Rachel Peragallo Urrutia, Melinda B Davis and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Karen Flores RosarioDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA. Electronic address: karen.flores.rosario@duke.edu.
Merna HussienDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA.
Phoenix GroverDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA.
Courtlyn WitteDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA.
Richa AgarwalDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA.
Jenna SkowronskiDivision of Cardiology, Department of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Johanna Quist-NelsonDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Michelle M KittlesonSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Rachel Peragallo UrrutiaDivision of General Obstetrics, Gynecology & Midwifery, Department of Obstetrics and Gynecology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Melinda B DavisDivision of Cardiovascular Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Joanna M JolyInova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
Dana SpearsDivision of Cardiology, Department of Medicine, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Julia Alvarenga Fagundes CoutoDepartment of Medicine, Duke University Hospital, Durham, North Carolina, USA.
Jerome Jeffrey FederspielDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina, USA; Division of Hematology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Melissa A DaubertDivision of Cardiology, Department of Medicine, Duke University Hospital, Durham, North Carolina, USA.

Funding

Duke Women's Reproductive Health Research ScholarsK12HD103083 · NICHD · DUKE UNIVERSITY · PI Cindy Amundsen · 2020 to 2026
$2.2M
NICHD NIH HHS K12 HD103083
6 · The paper itself

Abstract

Genetic testing is increasingly common for people with cardiomyopathies and arrhythmias, with cascade screening recommended for first-degree relatives of those carrying pathogenic or likely pathogenic variants. Consequently, a growing number of women of childbearing potential have been identified as being genotype-positive for cardiomyopathy and arrhythmia-associated genes. Knowledge of genotype-particularly in those with strong family history-may impact reproductive planning and guide interventions to reduce pregnancy-related risks. Herein, we outline the current landscape of genetic cardiomyopathies and discuss pregnancy-related considerations for affected women. We examine the limitations of existing pregnancy risk stratification models and highlight the role of multidisciplinary Pregnancy Heart Teams in optimizing maternal and fetal outcomes. We also review counseling points for genotype-positive women considering pregnancy, including preconception planning, preimplantation genetic testing, antenatal surveillance, and delivery planning. Finally, we address recommendations for postpartum management and provide illustrative cases to guide clinical care in this growing population.

Indexed as

arrhythmogenic cardiomyopathygenetic cardiomyopathyperipartum cardiomyopathypregnancy

Identifiers

PMID42132713
PMCPMC13309334

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.