In one paragraphArticle in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Ana Paula de Andrade SilvaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0009-0004-1639-8217 Erick Alves Dos SantosLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0002-3722-2518 Deborah Ribeiro FrazãoLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0001-9168-2606 Vinicius Ruan Neves Dos SantosLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0001-7887-3811 José Mario Matos-SousaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0001-8806-5500 Beatriz Risuenho PeinadoLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0003-0741-6730 Deiweson Souza-MonteiroLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0003-1843-4184 Wallacy Watson Pereira MeloLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0002-6769-1331 Zuleni Alexandre da SilvaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0009-0004-7359-0475 Everton Luiz Pompeu VarelaOxidative Stress Research Laboratory (LAPEO), Institute of Biological Sciences (ICB), Federal University of Pará (UFPA), Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0001-9710-3791 Jorddy Neves da CruzLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0003-0529-3714 Fabrício Mezzomo CollaresDental Materials Laboratory, Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande Do Sul, Porto Alegre, RS, 90010-150, Brazil.ORCID http://orcid.org/0000-0002-1382-0150 Renata Duarte de Souza-RodriguesLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil.ORCID http://orcid.org/0000-0002-1155-4768 Rafael Rodrigues LimaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street nº 1, Campus Do Guamá, Belém, PA, 66075-110, Brazil. rafalima@ufpa.br.ORCID http://orcid.org/0000-0003-1486-4013 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
This study evaluated the effect of N-acetylcysteine on oxidative biochemistry and bone damage during the development of ligature-induced experimental periodontitis in rats. The rats were divided into three groups (n = 8/group): control, experimental periodontitis (EP), or experimental periodontitis plus daily N-acetylcysteine administration (EP + NA) (100 mg/kg/day). Periodontitis was induced by bilateral silk ligatures on the mandibular first molars for 14 days. The antioxidant capacity of N-acetylcysteine was measured by (2,2-azinobis [3-ethylbenzothiazoline-6-sulfonate] (ABTS• +) and 1,1-dipheny-2-picrylhydrazyl (DPPH•) assays. Gingival samples were collected for analysis of oxidative parameters, while mandibles were used for histopathological evaluations of inflammation and collagen content, as well as for micro-computed tomography assessments of bone quality and vertical bone loss. Data were analyzed by Analysis of Variance (ANOVA), Multivariate Analysis of Variance (MANOVA), and Pearson's correlation (p < 0.05). N-acetylcysteine increased gingival antioxidant capacity and reduced lipid peroxidation compared with the experimental periodontitis group. Histopathological analysis showed that the experimental periodontitis plus daily N-acetylcysteine administration group, compared with the experimental periodontitis group, reduced inflammation, preserving collagen fibers, periodontal ligament, and alveolar bone. Microcomputed tomography analysis revealed improved bone quality and reduced alveolar bone loss in the experimental periodontitis plus daily N-acetylcysteine administration group. These findings suggest that systemic N-acetylcysteine has therapeutic potential in mitigating periodontitis in rats. Further studies are needed to establish its clinical applicability.
Indexed as
AcetylcysteineAlveolar Bone LossAntioxidantsOxidative StressPeriodontitisAnimalsDisease Models, AnimalGingivaLipid PeroxidationMaleRatsRats, WistarX-Ray MicrotomographyAcetylcysteineAntioxidantsAlveolar bone lossAntioxidantsN-AcetylcysteineOxidative stressPeriodontitis
Identifiers
PMID42133068
PMCPMC13503443
What Socratic holds
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