Evidence map›Paper›PMID 42133901›Full record

ArticleJCO precision oncology2026

Genomics of

Dean C Pavlick, Shruthi Rengarajan, Jessica K Lee, Deter X Jin, Garrett M Frampton, Bernard J Fendler, Andrej Savol, Ole Gjoerup, Hanna Tukachinsky, Richard S P Huang and 3 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dean C PavlickDepartment of Computational Discovery, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0001-6075-6246
Shruthi RengarajanDepartment of Computational Discovery, Foundation Medicine, Inc, Boston, MA.ORCID 0009-0009-0102-9597
Jessica K LeeDepartment of Clinical Development, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0002-4333-5092
Deter X JinDepartment of Computational Discovery, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0001-6545-1580
Garrett M FramptonDepartment of Computational Discovery, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0002-2361-2750
Bernard J FendlerDepartment of Computational Biology, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0001-7352-0689
Andrej SavolDepartment of Computational Biology, Foundation Medicine, Inc, Boston, MA.
Ole GjoerupDepartment of Clinical Development, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0001-9127-8769
Hanna TukachinskyDepartment of Clinical Development, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0002-0777-7555
Richard S P HuangDepartment of Clinical Development, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0001-8395-5168
Alexa B SchrockDepartment of Clinical Development, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0003-0106-9096
Jeffrey S RossDepartment of Pathology, Foundation Medicine, Inc, Boston, MA.ORCID 0000-0001-8494-2596
Andrea NecchiDepartment of Medical Oncology, IRCCS San Raffaele Hospital, Comprehensive Cancer Center, Milan, Italy.ORCID 0000-0002-3007-2756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMethylthioadenosine phosphorylase (

methods409,755 tissue biopsies (TBx) and 85,801 liquid biopsies (LBx) were sequenced using hybrid capture-based NGS (FoundationOne CDx or FoundationOne Liquid CDx), evaluating all classes of genomic alterations and circulating tumor DNA (ctDNA) tumor fraction (TF). Additionally, 6,740 TBx were subjected to both RNA and DNA sequencing to compare MTAP gene expression with genomic

resultsThe prevalence of pan-tumor

conclusion

Indexed as

GenomicsNeoplasmsPurine-Nucleoside PhosphorylaseFemaleHumansMale5'-methylthioadenosine phosphorylasePurine-Nucleoside Phosphorylase

Identifiers

PMID42133901
PMCPMC13182816

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.