Evidence map›Paper›PMID 42134178›Full record

ArticleClinics (Sao Paulo, Brazil)2026

Increased incidence of sudden sensorineural hearing loss in patients with rheumatoid arthritis: a nationwide propensity-matched cohort study.

Ming-Jenn Chen, Yu-Cheng Lee, Ming-Yao Chen, Chi-Hsiang Chung, Wu-Chien Chien, Ding-Yen Lin, Yung-Fu Wu, Kuen-Haur Lee

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Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ming-Jenn ChenDepartment of Surgery, Chi Mei Medical Center, Tainan, Taiwan; Department of Sports Management, College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
Yu-Cheng LeeGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taiwan.
Ming-Yao ChenDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Taipei Medical University, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare, Taiwan.
Chi-Hsiang ChungDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
Wu-Chien ChienDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
Ding-Yen LinDepartment of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Taiwan; Department of Pharmacology, College of Medicine, National Cheng Kung University, Taiwan.
Yung-Fu WuDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taiwan. Electronic address: prince1109@mail.ndmctsgh.edu.tw.
Kuen-Haur LeeProgram for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University-Shuangho Campus, Taiwan; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University-Shuangho Campus, New Taiwan, Taiwan; TMU Research Center for Digestive Medicine, Taipei Medical University, Taiwan; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, , Taiwan. Electronic address: khlee@tmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine whether Rheumatoid Arthritis (RA) is associated with an increased risk of incident Sudden Sensorineural Hearing Loss (SSNHL).

methodsThe authors conducted a nationwide, propensity-score-matched cohort study using Taiwan's Longitudinal Health Insurance Database (2000-2015). Adults with incident RA (n = 45,425) were matched 1:4 to those without RA controls (n = 181,700). The primary outcome was incident SSNHL (ICD-9-CM 389.10). Time-to-event analyses used Kaplan-Meier curves with log-rank tests and multivariable Cox regression. Landmark sensitivity analyses excluded SSNHL events within the first 1- and, separately, 5-years of follow-up.

resultsSSNHL occurred in 169/45,425 (0.37%) RA patients and 462/181,700 (0.25%) controls. RA was associated with a higher SSNHL risk (adjusted hazard ratio 2.695, 95% CI 2.248-3.231; p < 0.001). Kaplan-Meier and log-rank tests showed greater cumulative incidence in the RA cohort (p < 0.001). In landmark sensitivity analyses excluding events within the first 1- and 5-years, the association remained significant (Year 1: 34 vs. 45, p = 0.007; Year 5: 105 vs. 172, p < 0.001), indicating that the excess risk was not driven by very early events.

conclusionsThe present study revealed a high frequency of SSNHL in patients with RA, which highlights the importance of heightened clinical vigilance and prompt audiologic evaluation for hearing-related symptoms in this population.

Indexed as

Autoimmune diseaseCohort studyHearing loss screeningNational health insurance databaseRheumatoid arthritisSudden sensorineural hearing loss

Identifiers

PMID42134178
PMCPMC13196373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.