Evidence map›Paper›PMID 42134547›Full record

ArticleJournal of lipid research2026

The influence of blood lipids on cerebral perfusion by apolipoprotein E status.

Kevin P Decker, Nicholas A Rizzi, Zoe Rigas, Catherine Awad, Elizabeth M Habash, Mary K Kramer, Alexander M Cerjanic, Matthew L Cohen, Curtis L Johnson, Christopher R Martens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kevin P DeckerDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
Nicholas A RizziDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
Zoe RigasDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
Catherine AwadDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
Elizabeth M HabashDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA.
Mary K KramerDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.
Alexander M CerjanicDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Matthew L CohenDepartment of Communication Sciences & Disorders, University of Delaware, Newark, DE, USA.
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark, DE, USA.
Christopher R MartensDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, USA. Electronic address: cmartens@udel.edu.

Funding

Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI SLATER, JOHN HUNDLEY · 2016 to 2025
$23.3M
NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCIK01AG054731 · NIA · UNIVERSITY OF DELAWARE · PI MARTENS, CHRISTOPHER · 2017 to 2021
$723k
NIA NIH HHS K01 AG054731NIGMS NIH HHS P20 GM113125
6 · The paper itself

Abstract

Elevated blood lipids are strongly associated with increased risk of dementia due to Alzheimer's disease (AD). The apolipoprotein E (APOE) gene plays an important role in lipid transport and is a known genetic risk factor for the development of AD, with increased risk in ε4 carriers. Reduced cerebral blood flow (CBF) is known to precede the onset of AD pathology; however, the associations between blood lipids and cerebral perfusion by APOE status are not completely understood. This study included 65 midlife and older adults (≥50 years old), of which 18 (28%) carried the APOE ε4 allele. Using arterial spin labeling, we measured gray matter and white matter (WM) CBF, and hippocampal blood flow. Pearson correlations and simple linear regressions were used to assess the associations between blood lipids and cerebral perfusion. Serum triglycerides and very-low density lipoprotein cholesterol were negatively associated with GM CBF, WM CBF, and hippocampal blood flow in all participants. However, when stratified by APOE status, the negative associations of triglycerides and very-low density lipoprotein cholesterol on cerebral perfusion were more pronounced in ε4 carriers than non-ε4 carriers, despite no significant group differences in blood lipids. High-density lipoprotein cholesterol was positively associated with only WM CBF, without any differences between APOE status. No other blood lipids were associated with resting cerebral perfusion. These findings suggest that blood lipids can influence resting cerebral perfusion, and ε4 carriers are more negatively affected by this association which may partially explain the increased genetic risk for AD pathology.

Indexed as

Apolipoprotein E4Apolipoproteins ECerebrovascular CirculationLipidsAgedFemaleHumansMaleMiddle AgedApolipoprotein E4Apolipoproteins ELipidsand triglyceridesapolipoprotein Ecerebral blood flowhippocampuslipids

Identifiers

PMID42134547
PMCPMC13427847

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.