ReviewMovement disorders clinical practice2026
Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease.
Review in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is marked by pervasive uncertainty due to fluctuating motor and non-motor symptoms, variable treatment response, and an unpredictable clinical course. Intolerance of uncertainty (IU), a tendency to perceive ambiguity as threatening and respond with worry, avoidance, or decisional paralysis, may be consequential in PD, yet lacks a PD-focused synthesis.
objectiveTo synthesize conceptual, qualitative, and emerging quantitative literature on IU in idiopathic PD, describe clinical and psychosocial correlates across the illness trajectory, and identify implications for assessment and intervention.
methodsThis targeted narrative review searched MEDLINE (PubMed), Embase, PsycINFO, and Web of Science from inception to May 22, 2025, supplemented by reference screening and Parkinson's disease conference or guidance sources. English-language empirical and clinically informative papers addressing intolerance of uncertainty (IU) or closely related uncertainty constructs in adults with idiopathic PD and/or care partners were appraised at title/abstract and full-text levels, then charted for narrative synthesis.
resultsAcross qualitative, quantitative, intervention, and clinical review/guidance papers, symptom unpredictability, treatment uncertainty, identity disruption, shame, and future-planning concerns were linked with anxiety, demoralization, avoidance, reduced participation, and poorer quality of life.
conclusionIU may be a modifiable, common underlying pathway through which PD-related unpredictability, potentially influenced by dopaminergic, executive, and stress-system vulnerabilities, contributes to sustained psychological and functional burden. Advancing PD-sensitive measurement and testing IU-targeted interventions within multidisciplinary care models may improve adjustment and quality of life for patients and caregivers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.