Evidence map›Paper›PMID 42135656›Full record

ArticleBMC cancer2026

Comparison of laparoscopic versus open approach surgery for gastric gastrointestinal stromal tumors in unfavorable surgical locations.

Fangyao Zhou, Zhiyuan Liu, Sharvesh Raj, Bin Luo, Kunlong Chang, Jiayuan Zhang, Peng Zhang, Haibo Qiu, Bin Lai, Tao Chen and 10 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Fangyao Zhou *Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Zhiyuan Liu *Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Sharvesh RajDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Bin LuoDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Kunlong ChangDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Jiayuan ZhangDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Peng ZhangDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Haibo QiuDepartment of Gastric and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Bin LaiDepartment of General Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Tao ChenDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wenjun XiongDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yuan YinDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Xiangbin WanDepartment of General Surgery, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
Xiufeng LiuDepartment of Oncology, People's Liberation Army (PLA) Cancer Center, 81st Hospital of PLA, Nanjing, China.
Jian LiKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of GI Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Yan ZhaoDepartment of Gastric Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
Ye ZhouDepartment of Gastric and Soft Tissue Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Junjiang WangDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yong LiDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Xingyu FengDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. fengxingyu@gdph.org.cn.

Funding

Research Fund of CSCO-hengrui Oncology Y-HR2022QN-0383
6 · The paper itself

Abstract

introductionThe impact of postoperative and oncologic outcomes between laparoscopic (L) and open (O) surgical approaches for the resection of gastric gastrointestinal stromal tumors (G-GISTs) located in surgically unfavorable regions remains controversial. MATERIALS AND

methodsA retrospective analysis was conducted on 699 patients who underwent primary resection of G-GISTs at surgically unfavorable locations across 14 centers in China between 2001 and 2017. The patients were categorized into L and O surgery groups. To reduce bias due to baseline differences, propensity score matching (PSM) and multivariate Cox proportional hazards models were employed. Postoperative recovery metrics and long-term oncologic outcomes were compared between the matched cohorts.

resultsAfter 1:1 PSM, the L group exhibited a significantly shorter and lower postoperative hospital stay, intraoperative estimated blood loss and postoperative complication rate compared to the O group (all P < .010). Kaplan-Meier survival analysis with log-rank testing revealed no statistically significant differences in overall survival (OS) between the two groups (P = .190). Multivariate Cox proportional hazards analysis further indicated that the L approach was not associated with a significant reduction in mortality risk (hazard ratio [HR]: 1.41; 95% confidence interval [CI]: 0.56-3.60; P = .467).

conclusionLaparoscopic resection of G-GISTs located at surgically unfavorable sites was associated with improved short-term postoperative outcomes, including reduced blood loss, shorter hospital stays and fewer complications, compared to open surgery, but had comparable long-term oncologic outcomes.

Indexed as

GastrectomyGastrointestinal Stromal TumorsLaparoscopyStomach NeoplasmsAdultAgedBlood Loss, SurgicalChinaFemaleHumansKaplan-Meier EstimateLength of StayMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesGastrointestinal stromal tumorLaparoscopyLocationsOpen surgeryRecurrenceSurvival

Identifiers

PMID42135656
PMCPMC13343911

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.