ArticleJournal of the science of food and agriculture2026
Myrtle berry juice improves hematological parameters and alleviates oxidative stress and inflammation in the myocardium of rats fed a high-fat diet: A combined in vivo and in silico investigation.
Article in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundObesity induced by high-fat diet (HFD) is a major risk factor for cardiovascular diseases. This study aims to evaluate the protective mechanism by which myrtle berry juice (MBJ) exhibits its anti-obesity and cardioprotective effects in HFD-fed rats. Additionally, the potential molecular mechanisms of delphinidin-3-O-glucoside, one of the bioactive compounds in myrtle berries, are investigated in silico. Male Wistar rats were fed an HFD for 6 weeks to induce obesity. They were then treated daily with either MBJ (10 mL kg
resultsFeeding HFD significantly elevated body weight and cardiac hypertrophy as well as myocardial total cholesterol, triacylglycerol and low-density lipoprotein. HFD induced also an oxidative stress status characterized by increased MDA levels, decreased antioxidant enzyme activities (SOD, CAT, GPx) and non-enzymatic antioxidants (GSH, SH), as well as myocardial reactive oxygen species (H
conclusionMBJ showed significant cardioprotective and hematoprotective effects against cardiac dysfunction and hematological alterations induced by HFD. © 2026 Society of Chemical Industry.
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