Observational studyBrain and behavior2026
The Correlation Between Apathy and the Efficacy of Rehabilitation in Patients With Parkinson's Disease: A Retrospective Observational Study.
Observational study in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundApathy impacts mood and social functioning in patients with Parkinson's disease (PWP), and its effect on motor rehabilitation outcomes remains unexplored.
objectiveThis study evaluates whether the presence of apathy (apathy status) is associated with rehabilitation outcomes in PWP.
methodsWe retrospectively analyzed records of 122 PWP (Hoehn-Yahr stage ≤ 3) who underwent a 2-week multidisciplinary intensive rehabilitation treatment (MIRT) between April 2020 and July 2024, dividing them into Parkinson's disease with apathy (PDA+, score > 14) and without apathy (PDA-, score ≤ 14) based on Modified Apathy Evaluation Scale (MAES). The outcome measures included the Movement Disorder Society Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS III), the Modified Parkinson Activity Scale (M-PAS), the Five Times Sit to Stand Test (FTSTS), the Timed Up and Go Test (TUG), and the 10-Meter Walk Test (10MWT). We conducted group comparisons and employed multiple linear regression analyses, treating the MAES both as a dichotomous variable and as a continuous predictor. In these analyses, we adjusted for baseline measures of MDS-UPDRS III, FTSTS, and TUG. Additionally, we performed sensitivity analyses using alternative cutoffs (MAES > 13 and > 15).
resultsFollowing MIRT, the PDA- group (n = 75) showed significant improvements in MDS-UPDRS III, M-PAS, FTSTS, and TUG (p < 0.001, p < 0.001, p = 0.011, and p < 0.001, respectively). In contrast, no such improvements were observed in the PDA+ group (n = 47). The improvements in MDS-UPDRS III, FTSTS, and TUG scores exhibited significant differences between the groups (p = 0.018, p = 0.046, and p = 0.042, respectively). In multivariable linear regression with MAES as a continuous variable, higher MAES was independently associated with smaller ΔMDS-UPDRS III (β = 0.147, 95% CI 0.017-0.277, p = 0.027; R
conclusionsBaseline apathy severity was associated with attenuated motor improvement after MIRT in PWP; understanding its mechanisms is crucial for personalized rehabilitation and treatment effectiveness.
trial registrationClinicalTrials.gov identifier: ChiCTR2000033768, 2020/06/11.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.