Evidence map›Paper›PMID 42136384›Full record

ReviewMolecular microbiology2026

The Complexity of erm-Mediated Resistance: Structural and Functional Perspectives From β-Hemolytic Streptococci.

Lillie M Powell, Rita Berisio, P Rocco LaSala, Slawomir Lukomski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lillie M PowellDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Rita BerisioInstitute of Biostructure and Bioimaging, National Research Council, CNR, Naples, Italy.
P Rocco LaSalaDepartment of Pathology and Laboratory Medicine, University of Connecticut Health, Farmington, Connecticut, USA.
Slawomir LukomskiDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.ORCID 0000-0002-5159-1838

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrolide overuse and resulting resistance crippled the applicability of one of the most important and successful classes of antibiotics. The rising incidence of invasive infections caused by β-hemolytic group A and group B streptococci have been paralleled with marked increases in erythromycin and clindamycin resistance. As a result, resistant invasive group A and group B Streptococcus infections have been classified by the CDC as a concerning level threat since 2019. Acquisition of erythromycin resistance methylase (erm) genes is a major contributor of the MLS

Indexed as

Drug Resistance, BacterialMethyltransferasesAnti-Bacterial AgentsBacterial ProteinsErythromycinHumansLincosamidesMacrolidesRNA, RibosomalStreptococcal InfectionsStreptococcus pyogenesAnti-Bacterial AgentsBacterial ProteinsErythromycinLincosamidesMacrolidesMethyltransferasesRNA, Ribosomalantimicrobial resistanceerminvasive group A StreptococcusmethylationMLSB

Identifiers

PMID42136384
PMCPMC13353660

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.