SynthesisOncology reviews2026
Rebound regrowth phenomenon in patients with pediatric low-grade gliomas treated with MAPK inhibitors - a systematic review.
Synthesis in Oncology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Mitogen-activated protein kinase pathway inhibitors (MAPKi) are an important therapeutic option for patients with unresectable, symptomatic or progressive pediatric low-grade gliomas (pLGGs). Despite high disease control rates during treatment, tumor regrowth following MAPKi discontinuation has been reported. This phenomenon, termed rebound regrowth (RR), appears biologically and clinically distinct from classic off-therapy progression or acquired resistance to MAPKi. However, the incidence, timing, and predictors of RR remain poorly defined. This systematic review synthesizes evidence on RR following MAPKi discontinuation in pLGG. Methods: A systematic literature review was conducted according to PRISMA 2020 guidelines. Eligible studies included clinical trials, cohort studies, and case reports/series, involving patients aged 0-25 years with NF1-associated or sporadic pLGG, who experienced RR after MAPKi dose reduction or discontinuation. RR was defined as radiological progression within 6 months after treatment cessation. Cohort-level and individual patient-level data were extracted. Results: Twenty publications met inclusion criteria. Among ten studies involving ≥10 patients, RR was documented in at least 23 of 131 evaluable individuals. Additionally, individual-level data of 21 patients were analyzed. Most RR events occurred early after MAPKi cessation, were detected radiologically and clinically asymptomatic. RR was reported most frequently in tumors harboring the Conclusion: RR is a reproducible and clinically relevant phenomenon following MAPKi discontinuation in pLGG. Standardized definitions, structured post-discontinuation surveillance, and prospective evaluation of treatment duration and dose-tapering strategies are needed to optimize MAPKi discontinuation and long-term disease management in patients with pLGG.
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