A chemo-selective deprotection-cyclization strategy enables fluorescence imaging of hydroxylamine and reveals its pathological role in Parkinson's disease.

Shunping Zang, Jia Ke, Hanbing Zheng, Qing Liu, Liu Yang, Chaoyi Yao, Benhua Wang, Minhuan Lan, Xiangzhi Song

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Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shunping ZangCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.

Jia KeLiangzhu Laboratory, Zhejiang University Medical Center Hangzhou Zhejiang 311121 P.R. China.

Hanbing ZhengCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.

Qing LiuCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.

Liu YangCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.

Chaoyi YaoCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.

Benhua WangCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.ORCID https://orcid.org/0000-0001-9084-2209

Minhuan LanCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.ORCID https://orcid.org/0000-0003-0464-8886

Xiangzhi SongCollege of Chemistry and Chemical Engineering, Central South University Changsha Hunan 410083 P.R. China chaoyiyao@csu.edu.cn benhuawang@csu.edu.cn xzsong@csu.edu.cn.ORCID https://orcid.org/0000-0002-4034-6386

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxylamine (HA), a reactive nitrogen species generated by neuronal nitric oxide synthase (nNOS), has been largely overlooked in neurodegenerative disorders. Herein, we report the first identification of HA overexpression in Parkinson's disease (PD) and elucidate its pathological role using chemo-selective fluorescence imaging combined with proteomic analysis. A general HA-responsive probe platform was developed by introducing a 1-(4,4-dimethyl-2,6-dioxacyclohexylidene)ethyl (Dde) unit as a highly specific HA-recognition motif. Among the resulting probes, DCI-HA-2 exhibited remarkable sensitivity, a fast response, and excellent selectivity toward HA. Using DCI-HA-2, elevated HA levels were visualized in PD cells, PD model mice, and brain tissues for the first time. Mechanistically, nNOS-derived HA suppresses cystathionine β-synthase (CBS) expression, leading to impaired hydrogen sulfide (H

Identifiers

PMID42137307

DOI10.1039/d6sc01655c

PMCPMC13169071

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LicenceCC BY-NC

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