ArticleFrontiers in pharmacology2026
Anxiolytic and cognitive effects of dietary phenolics in zebrafish: rosmarinic acid, gallic acid, and 3-hydroxytyrosol.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Rosmarinic acid (RA), gallic acid (GA), and 3-hydroxytyrosol (3-HT) are phenolic compounds abundant in medicinal plants traditionally used to support cognitive function and neurological wellbeing. Although their antioxidant and neuroprotective properties are well documented in mammalian systems, their behavioral effects remain insufficiently explored in alternative Methods: In this study, we investigated the anxiolytic and cognitive-enhancing potential of RA, GA, and 3-HT in adult zebrafish ( Results: RA significantly increased the top/bottom time ratio ( Discussion: Together, these findings reveal distinct neurobehavioral profiles for each phenolic compound: RA exhibited pronounced anxiolytic activity, while GA and 3-HT primarily enhanced cognitive performance, with 3-HT exerting broad-spectrum memory-facilitating effects. Overall, these results underscore the value of zebrafish as a translational model for behavioral pharmacology and support the ethnopharmacological relevance of RA, GA, and 3-HT as potential candidates for further investigation in the context of anxiety and cognitive disorders.
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