ReviewFrontiers in endocrinology2026
Sentinel factors for mild cognitive impairment in type 2 diabetes mellitus and their interaction mechanisms: a narrative review with network analysis perspective.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- FT3 combined with the TyG index for risk stratification of mild cognitive impairment in euthyroid patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus (T2DM) is a global chronic metabolic epidemic, and affected patients face a 1.5-fold higher risk of mild cognitive impairment (MCI) - a reversible pre-dementia stage - than non-diabetic populations. Early identification of modifiable sentinel factors is the cornerstone of delaying cognitive decline in T2DM patients, yet traditional statistical methods cannot fully elucidate the synergistic interactions between multi-dimensional risk factors. Network analysis, a graph theory-based statistical approach, enables visualization of complex variable associations and identification of core regulatory nodes in disease networks, providing a novel perspective for MCI research. Based on our team's clinical data and comprehensive evidence synthesis, this review systematically summarizes the pathophysiological mechanisms linking T2DM and MCI, establishes an operational definition and classification framework of MCI sentinel factors in T2DM patients, elaborates the application value of network analysis in this field, and proposes concrete research paradigms for future investigation. This review aims to provide a theoretical and practical framework for the early screening, targeted intervention, and precise prevention of MCI in T2DM patients, aligning with the scope of clinical diabetes and geriatric endocrinology research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.