ReviewFrontiers in endocrinology2026
Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeostasis through the "gut-bone axis," and this review consolidates its diverse mechanisms. GM-derived metabolites directly/indirectly modulate osteoclast/osteoblast activity. GM also regulates systemic immunity to influence the RANKL/OPG pathway and mediates endocrine signals. Furthermore, it modulates intestinal barrier integrity to facilitate mineral/vitamin absorption and interacts with the nervous system to form the "microbiota-gut-brain-bone" axis. GM imbalance, resulting from factors such as aging, hormonal shifts, or dietary habits, promotes the progression of OP through the perturbation of these networks. This review evaluates the therapeutic potential of GM-targeted interventions, including probiotics, prebiotics, and fecal microbiota transplantation, and underscores the GM as a pivotal therapeutic target, emphasizing that future therapeutic strategies for OP must incorporate the interconnected GM-bone axis for efficacious prevention and treatment.
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