Evidence map›Paper›PMID 42137601›Full record

ArticleMolecular therapy. Advances2026

Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates.

Célia Sourd, Joel Quinn, Molly C John, Cristina Martinez-Fernandez de la Camara, Lakshanie C Wickramasinghe, Moustafa Attar, Hoda Shamsnajafabadi, Ahmed Salman, Sally A Cowley, Calliope A Dendrou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Célia SourdNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Joel QuinnNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Molly C JohnNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Cristina Martinez-Fernandez de la CamaraNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Lakshanie C WickramasingheThe Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
Moustafa AttarThe Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
Hoda ShamsnajafabadiNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Ahmed SalmanNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Sally A CowleyJames and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Calliope A DendrouThe Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
Robert E MacLarenNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Jasmina Cehajic-KapetanovicNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Kanmin XueNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adeno-associated viral (AAV) vectors are rapidly advancing as gene therapies for retinal diseases, but gene therapy-associated uveitis (GTAU) limits their broader application. We assessed the ocular immune response to subretinal AAV gene therapy in two non-human primates (NHPs): NHP1 received bilateral AAV2-CAG-

Indexed as

AAVgene therapygene therapy-associated uveitissingle-cell transcriptomic analysisspatial transcriptomics

Identifiers

PMID42137601
PMCPMC13148909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.