ArticleJournal of the Endocrine Society2026
Clinical characteristics, disease course, and clinical subgroups of young adults with type 2 diabetes.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Context: Type 2 diabetes (T2D) in young adults is an emerging entity distinct from that in older adults. Objective: To identify unique clinical subgroups among young adults using clinical variables. Methods: Utilizing the Utah Diabetes Database, a retrospective cohort study was performed with data from 56 327 individuals with T2D as defined by International Classification of Diseases codes and analyzed by predefined groups: young adults (18-44 years) and older adults (≥45 years). De novo k-means clustering was performed. Results: Young adults with T2D (yT2D) were more likely to be female (51%), self-identify as racial/ethnic minorities (24%), and have obesity (68%). Compared to older adults, yT2D at baseline had worse glycemic control (hemoglobin A1c [HbA1c] 7.8 ± 2.5% vs 7.3 ± 2.0%, Conclusion: yT2D have worse glycemic control, greater obesity, and similar renal decline compared with older adults with T2D. A high-risk subgroup of yT2D presents with a significantly lower eGFR. More research is needed to determine whether targeted therapy to high-risk groups will reduce diabetes-related complications.
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