ReviewInternational journal of molecular medicine2026
Spatial hepatology: Decoding liver zonation for metabolic and regenerative therapeutics (Review).
Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of spatial omics and single‑cell technologies has redefined liver zonation as a dynamic regulator of regeneration, extending beyond its traditional role in metabolic compartmentalization. This progress has given rise to the emerging field of 'spatial hepatology', which aims to integrate spatial information with molecular features. Compared with conventional bulk or single‑cell approaches, spatial hepatology incorporates tissue architecture into molecular analyses, thereby revealing region‑specific regulatory mechanisms during liver regeneration and disease progression. From this perspective, the present review proposes the concept of zonation‑guided therapeutic strategies. It systematically summarized recent advances in the molecular mechanisms governing liver zonation, examined the role of zonal disruption in liver disease pathogenesis, clarified the dynamic functions of zonated hepatocytes during regeneration and outlined related targeted therapeutic approaches. The present review aimed to establish a framework that integrates basic research with clinical application, providing a theoretical basis for precision hepatology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.