ArticleJournal of immunology research2026
High Fat Diet-Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss.
Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- High Fat Diet-Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss.Journal of immunology research · 2026Article
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9 authors.
Funding
Abstract
Obesity is recognized as a chronic low-grade inflammation that contributes to metabolic disorders. Weight loss (WL) is well known to improve metabolic disorders. However, recent studies have shown that the changes in immune cells associated with obesity exhibit immunological memory even after WL. Obesity impairs skin barrier function and exacerbates inflammatory skin diseases, such as psoriasis. While skin immune cells maintain homeostasis and defense, the impact of obesity on these cells in intact skin is understudied, as research mainly focuses on skin with an inflammatory skin disease model in the context of obesity. The effect of WL on skin immunity is even less clear. Therefore, this study aimed to investigate these discrepancies. Mice were assigned to the lean group (regular diet), the obese group (high-fat diet for 18 weeks), and the WL group (high-fat diet for 9 weeks followed by regular diet for 9 weeks). Following 18 weeks of feeding, mouse skin was excised, and immune cell populations within the skin were analyzed using real-time PCR and flow cytometry. In addition, the effects of WL on psoriasis were examined using an imiquimod-induced psoriasis mouse model. We observed increased expression of RORγt, IL-17A, and CCL20 in intact skin in both the obese and WL groups. In the psoriasis model, disease severity was further exacerbated by WL. Moreover, whereas the Vγ4
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