ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Supramolecular Assembly of Stepped-Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
ROS-based tumor elimination could trigger systemic antitumor immune responses. However, these strategies are fundamentally restricted by insufficient ROS generation and uncontrollable kinetic processes. Besides, tumor-associated macrophages often reverted to an immunosuppressive phenotype due to a lack of sustained stimulation. To achieve both effective tumor eradication and sustained activation of tumor immune microenvironment, a stepped-persistent ROS nanogenerator supramolecularly assembled multiple ROS generation modules was synthesized. G-quadruplexes (G4s)-DNA nanochains, functionalized with Hemin and Ce6, served as a structure-directing agent for synthesizing polydopamine nanofibers (PDANFs). Semiquinone radicals generated during dopamine polymerization were stabilized by supramolecular interaction between G4s and polydopamine oligomers. Under NIR irradiation, PDANFs could explosively produce singlet oxygen (
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