ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Mechanisms of Pericyte-Mediated Cancer Metastasis.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Impact ofOncology research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Emerging experimental evidence shows that perivascular cells (PCs), referred to as pericytes lying within the basement membrane (BM) and surrounding endothelial cells (ECs) of microvasculatures, play multifarious roles in cancer metastasis. In the tumor microenvironment (TME), PC detachment and ablation from tumor microvessels obliterate the vascular integrity and the protective barrier of the vessel wall, leading to increased permeability for cancer cell intravasation. PCs retain mesenchymal stem cell (MSC) features and commit to differentiation into other stromal cells, including the pericyte-fibroblast transition (PFT) for promoting cancer metastasis. Activated PCs produce a myriad of growth factors, cytokines, and chemokines, which promote invasiveness and dissemination of cancer cells by altering tumor angiogenic, inflammatory, and immune microenvironment. Owing to their high lineage and phenotypic plasticity, PCs significantly constitute to the pre-metastatic niche formation in distal organs. This review provides an updated overview and mechanistic insights into each of PC-mediated critical processes of the metastatic cascade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.