Evidence map›Paper›PMID 42139345›Full record

ArticleScience advances2026

Architecture of clathrin-independent AP3:ARF1-coated carriers.

Jonathan G G Kaufman, Grigory Tagiltsev, Danièle S Stalder, Rebecca J Taylor, Ioana Sava, Hui Guo, Katarzyna A Ciazynska, Nathan R Zaccai, Sally R Gray, Yvonne Vallis and 5 more

Abstract read
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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jonathan G G KaufmanCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.ORCID 0000-0001-5320-8401
Grigory TagiltsevDepartment of Cell and Virus Structure, Max Planck Institute of Biochemistry, Martinsried 82512, Germany.ORCID 0000-0002-9312-2108
Danièle S StalderCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Rebecca J TaylorDepartment of Cell and Virus Structure, Max Planck Institute of Biochemistry, Martinsried 82512, Germany.ORCID 0000-0001-8147-3130
Ioana SavaCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Hui GuoDepartment of Cell and Virus Structure, Max Planck Institute of Biochemistry, Martinsried 82512, Germany.ORCID 0000-0001-7007-2876
Katarzyna A CiazynskaMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.ORCID 0000-0002-9899-2428
Nathan R ZaccaiCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.ORCID 0000-0002-1476-2044
Sally R GrayCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.ORCID 0000-0003-2567-3319
Yvonne VallisInstitute of Science and Technology, Klosterneuburg 3400, Austria.ORCID 0000-0002-5408-5906
Stefan HöningInstitute for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.ORCID 0000-0002-5432-6976
Bernard T KellyCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.ORCID 0000-0003-2666-6268
David C GershlickCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.ORCID 0000-0002-0602-210X
John A G BriggsDepartment of Cell and Virus Structure, Max Planck Institute of Biochemistry, Martinsried 82512, Germany.ORCID 0000-0003-3990-6910
David J OwenCambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.ORCID 0000-0002-8351-6322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The AP3 complex mediates cargo sorting and carrier assembly for the trafficking of transmembrane proteins from endosomes to lysosomes. AP3 is generally believed to localize to clathrin-free, ARF1-positive, elongated carriers in cells, but the architecture of AP3-based coats was unknown. Using in vitro reconstitution and cryo-electron tomography, we demonstrate that AP3:ARF1 spontaneously remodels membranes containing cargo and the phosphoinositide PI(3,5)P

Indexed as

Adaptor Protein Complex 3ADP-Ribosylation Factor 1ClathrinAnimalsEndosomesHumansLysosomesProtein TransportAdaptor Protein Complex 3ADP-Ribosylation Factor 1Clathrin

Identifiers

PMID42139345
PMCPMC13178560

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.