Evidence map›Paper›PMID 42139356›Full record

ArticleScience advances2026

An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling.

Irena Selicharová, Nicholas S Kirk, Anna Kertisová, Marta Lubos, Katarína Mitrová, Terezie Ticháčková, Lenka Žáková, Martina Chrudinová, Jana Březinová, Karel Harant and 4 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Irena SelicharováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0000-0002-0180-6781
Nicholas S KirkWEHI, 1G Royal Parade, Parkville, Victoria 3052, Australia.ORCID 0000-0001-5028-6308
Anna KertisováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0009-0001-8278-9652
Marta LubosInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0000-0002-2919-0085
Katarína MitrováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.
Terezie TicháčkováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0000-0003-2706-1295
Lenka ŽákováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0000-0001-6439-2574
Martina ChrudinováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.
Jana BřezinováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0000-0002-2076-9891
Karel HarantInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.
Jan VoldřichInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0009-0006-9001-807X
Miroslav HájekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0000-0002-8906-243X
Derek M HuffmanDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jiří JiráčekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16000 Praha 6, Czech Republic.ORCID 0000-0003-3848-2773

Funding

Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2010 to 2024
$10.8M
NIA NIH HHS P30 AG038072
6 · The paper itself

Abstract

Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, TyrB32]-insulin (

Indexed as

InsulinProtein EngineeringReceptor, IGF Type 1Receptor, InsulinSignal TransductionAnimalsHumansMiceNeuronsProtein BindingRatsInsulinReceptor, IGF Type 1Receptor, Insulin

Identifiers

PMID42139356
PMCPMC13178572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.