ArticleTranslational psychiatry2026
Neural imbalance between feedback sensitivity and motor inhibition in compulsivity and negative urgency.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Compulsivity and emotional impulsivity (negative urgency) are considered transdiagnostic risk factors for compulsive-impulsive psychopathology that is linked to a neural imbalance between executive and motivational-emotional systems. However, existing evidence does not derive from within-subjects designs, leaving it unclear whether imbalance occurs with high expressions in compulsivity and negative urgency. To address this gap, we conducted a preregistered analysis to examine how feedback sensitivity and motor inhibition interact as a function of compulsivity and negative urgency.Participants (n = 205; collected 2018-2019) expressing a wide range in compulsivity and impulsivity performed two motor inhibition and two feedback tasks during electroencephalography. We examined how the relationship between neural correlates of motor inhibition (nogo/stop>go) and feedback sensitivity (loss>gain) was moderated by compulsivity and negative urgency. Compulsivity emerged as the most robust moderator. Across multiple tasks, feedback sensitivity was associated with motor inhibitory activity in participants with mild, but not severe, compulsivity. A similar effect was observed in low versus high negative urgency. The moderation by compulsivity remained when controlling for negative urgency, and vice versa. These results suggest a neural imbalance between systems tied to motor inhibition and feedback sensitivity in transdiagnostic risk. This imbalance manifests such that strong motivational-emotional sensitivity is insufficiently compensated by motor inhibitory resources. It could drive repetitive or rash behaviors in response to distress in compulsivity and negative urgency, respectively. Whereas shared mechanisms may underlie compulsivity and negative urgency, the current interactions appear to also reflect processes unique to each construct.
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