ArticleBMC nephrology2026
Torque teno virus viral load and hospitalisation for infections in long-term kidney transplant recipients: a single-centre prospective cohort study.
Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
backgroundTorque teno virus (TTV) viral loads may reflect patients' net state of immunosuppression and identify patients at risk of infections and rejection early after solid organ transplantation. However, its role in long-term kidney recipients (KTRs) is less clear.
methodsThis single-centre prospective cohort study evaluated the association between TTV viral load at recruitment and severe infections requiring hospitalisation within 12 months as the primary outcome in kidney recipients > 1-year post-transplant and on stable immunosuppression for > 3 months. Participants were followed up for 12 months, until change of immunosuppression, graft loss, or death. Pre-specified, exploratory secondary outcomes, including opportunistic infections, malignancy, composite outcomes were also analysed.
resultsMedian time after transplant amongst the 171 included participants was 10.3 years (interquartile range (IQR) 4.9-16.0). Thirty-one developed severe infections 105 days (IQR 65-204) after baseline TTV measurement. Higher baseline log10-transformed TTV viral load (logTTV) was associated with severe infections within 12 months (odds ratio (OR) 1.37, 95% confidence interval (CI) 1.01-1.86, p = 0.045) with a modest area under receiver operating characteristics curve of 0.60 (95% CI 0.50-0.71). Compared to logTTV < 4.6 copies/mL, logTTV > 6.6 copies/mL (hazard ratio (HR) 3.45, 95% CI 1.10-10.9, p = 0.04) was associated with time to hospitalisations for infections but not logTTV 4.6-6.6 copies/mL (HR 2.30, 95% CI 0.97-5.47, p = 0.06). The ORs for the association between logTTV and malignancy, opportunistic infection and biopsy-proven rejection were 1.86 (95% CI 1.09-3.16), 1.21 (95% CI 0.69-2.13) and 1.09 (95% CI 0.70-1.69) respectively.
conclusionElevated TTV viral loads were associated with severe infections amongst our cohort of long-term KTRs and may be a useful biomarker in this population.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.