Evidence map›Paper›PMID 42143021›Full record

ArticleCell2026

The temporal architecture of the seminiferous epithelial cycle revealed by spatial transcriptomics.

Arun Chakravorty, Jina Yun, Henry Amrhein, Katsuya L Colón, Toshiyuki Sato, Benjamin D Simons, Shosei Yoshida, Long Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arun ChakravortyCalifornia Institute of Technology, Department of Biology and Biological Engineering, Pasadena, CA 91125, USA; UCLA-Caltech Medical Scientist Training Program, Los Angeles, CA 90095, USA.
Jina YunCalifornia Institute of Technology, Department of Biology and Biological Engineering, Pasadena, CA 91125, USA.
Henry AmrheinCalifornia Institute of Technology, Department of Biology and Biological Engineering, Pasadena, CA 91125, USA.
Katsuya L ColónCalifornia Institute of Technology, Department of Biology and Biological Engineering, Pasadena, CA 91125, USA.
Toshiyuki SatoDivision of Germ Cell Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan; Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Benjamin D SimonsGurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK. Electronic address: bds10@cam.ac.uk.
Shosei YoshidaDivision of Germ Cell Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan; Graduate Institute for Advanced Studies, SOKENDAI, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan. Electronic address: shosei@nibb.ac.jp.
Long CaiCalifornia Institute of Technology, Department of Biology and Biological Engineering, Pasadena, CA 91125, USA. Electronic address: lcai@caltech.edu.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

Spermatogenesis features the seminiferous epithelial cycle, a periodic progression of germ-cell differentiation along the seminiferous tubules. Using seqFISH+ spatial transcriptomics, we profiled 2,653 genes in 867,062 mouse testis cells, revealing tubule-level transcriptional patterns that recapitulate the cycle and enable high-resolution temporal mapping of cells. Unlike other somatic cells, Sertoli cells exhibit a cyclic transcriptional profile synchronized with spermatogenesis. This cyclicity persists in germ-cell-depleted testes (busulfan and W/W

Indexed as

Seminiferous EpitheliumSpermatogenesisAnimalsMaleMiceMice, Inbred C57BLSertoli CellsSpatial TranscriptomicsTestisTranscriptomeTretinoinTretinoinbiological oscillatorblood-testis barriercell-cell signalingcell synchronizationmouse testispermissive signalretinoic acidseminiferous epithelial cycleseqFISH+Sertoli cellsspatial biologyspatial transcriptomicsspermatogenesistemporal dynamicsWnt signaling

Identifiers

PMID42143021
PMCPMC13326559

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.