Evidence map›Paper›PMID 42143191›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Synergistic interaction between lead and cadmium via metal-transporter gene upregulation in mice.

Tingting Zhang, Weiqin Xing, James A Ippolito, Shuangshuang Shao, Xinjun Huang, Yongqiang Yang, Linlin Zhao, Yongxia Cheng, Liping Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tingting ZhangSchool of the Environment, Henan University of Technology, Zhengzhou, 450001, Henan, China.ORCID http://orcid.org/0009-0000-7121-8910
Weiqin XingSchool of the Environment, Henan University of Technology, Zhengzhou, 450001, Henan, China.ORCID http://orcid.org/0000-0001-7557-9940
James A IppolitoSchool of Environment and Natural Resources, The Ohio State University, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0001-8077-0088
Shuangshuang ShaoSchool of Environmental and Bioengineering, Henan University of Engineering, Zhengzhou, 451191, Henan, China.ORCID http://orcid.org/0000-0001-8581-1010
Xinjun HuangSchool of the Environment, Henan University of Technology, Zhengzhou, 450001, Henan, China.ORCID http://orcid.org/0000-0002-6851-4716
Yongqiang YangSchool of the Environment, Henan University of Technology, Zhengzhou, 450001, Henan, China.ORCID http://orcid.org/0000-0002-7109-6164
Linlin ZhaoJiyuan Ecological and Environmental Monitoring Center of Henan Province, Jiyuan, 459000, Henan, China.
Yongxia ChengHenan International Joint Laboratory of Environmental Pollution, Remediation and Food Quality Security, Zhengzhou, 450001, Henan, China.
Liping LiSchool of the Environment, Henan University of Technology, Zhengzhou, 450001, Henan, China. lilp@haut.edu.cn.ORCID http://orcid.org/0000-0003-0589-5336

Funding

Education Department of Henan Province 24A610002National Natural Science Foundation of China 42207366Science and Technology Department of Henan Province 242300420281Science and Technology Department of Henan Province 252300421834
6 · The paper itself

Abstract

This study investigated the potential synergistic interactions between Pb and Cd, and assessed the contribution of transporter gene expression to the synergism. Mice were administered varying doses of Pb (15, 30 and 108 mg kg

Indexed as

CadmiumCation Transport ProteinsLeadUp-RegulationAnimalsDrug SynergismKidneyLiverMaleMiceSolute Carrier Family 11, Member 2CadmiumCation Transport ProteinsLeadSLC39A14 protein, mouseSlc39a8 protein, mouseSolute Carrier Family 11, Member 2CadmiumExpressionGeneLeadSynergismTransporter

Identifiers

PMID42143191
PMCPMC13518445

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.