ArticleAnnals of medicine2026
The plasma metabolome and clinical features of patients with coeliac disease in Northwest China.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Celiac disease and the gut microbiota: bibliometric mapping of research hotspots and immune-mechanistic trends.Frontiers in immunology · 2026Pooled it
- Letter to the editor regarding 'the plasma metabolome and clinical features of patients with coeliac disease in Northwest China'.Annals of medicine · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCoeliac disease (CeD) is a relatively common autoimmune disease in Caucasian populations, but is rarely reported in China. The metabolic characteristics of Chinese patients with coeliac disease remain insufficiently characterised. Therefore, this study attempted to describe the metabolic profile of a small cohort Chinese patients with coeliac disease.
methodsPlasma samples and dietary pattern information were collected from 15 patients with CeD, 15 healthy volunteers, and 30 patients with inflammatory bowel disease (IBD). Plasma metabolomic analysis was performed using a pseudo-targeted metabolomics approach based on ultra-high-performance liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry (UHPLC-QTRAP-MS). Dietary intake was assessed
resultsDespite reporting significantly higher daily intakes of protein and carbohydrate when compared to controls or IBD patients, CeD patients exhibited a relative insufficiency of micronutrient niacin. Several distinct metabolic alterations were identified in CeD patients relative to healthy controls, independent of dietary intake. These included decreased metabolites in the pentose phosphate pathway and increased intermediates of the citric acid cycle. The abundances of L-proline, D-proline, microbiota-related aromatic amino acid metabolites, glycine-conjugated bile acids, and the plant sterol panuosterone were increased. In contrast, the abundances of several long-chain acylcarnitines were reduced despite higher fat intake. These metabolic alterations existed in CeD but not in IBD patients.
conclusionsCeD patients in Northwest China exhibit a unique metabolic profile distinct from IBD and healthy controls, involving host central carbon metabolism, glycerophospholipid metabolism, gut microbiota, and other factors. This might underscore the multifactorial nature of coeliac disease, implicating other factors beyond genetics and gluten.
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