Evidence map›Paper›PMID 42145589›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Effect of ancestry and shared genetic architecture of serious mental illness on symptoms and cognition in an admixed Latin American population.

Esteban Lopera-Maya, Susan K Service, Ana M Díaz-Zuluaga, Mauricio Castaño Ramírez, Juan Camilo Mejia, Johanna Valencia, Terri Teshiba, Ana Maria Ramirez, Juan F De la Hoz, Jonathan Valdez and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Esteban Lopera-MayaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.ORCID 0000-0001-5862-3938
Susan K ServiceCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Ana M Díaz-ZuluagaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Mauricio Castaño RamírezDepartment of Mental Health and Human Behavior, University of Caldas, Manizales, Colombia.
Juan Camilo MejiaResearch Group in Psychiatry GIPSI, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellin, Colombia.
Johanna ValenciaResearch Group in Psychiatry GIPSI, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellin, Colombia.
Terri TeshibaCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Ana Maria RamirezCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Juan F De la HozCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Jonathan ValdezCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Marfred Munoz UmanesCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Tyler M MooreDepartment of Psychiatry, University of Pennsylvania School of Medicine; Philadelphia, USA.
Sinéad ChapmanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Benjamin M NealeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1513-6077
Carrie E BeardenCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.ORCID 0000-0002-8516-923X
Javier I EscobarDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.
Ruben C GurDepartment of Psychiatry, University of Pennsylvania School of Medicine; Philadelphia, USA.
Victor I ReusDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, USA.
Chiara SabattiDepartments of Biomedical Data Science and Statistics, Stanford University, Stanford, USA.
Loes Olde LoohuisCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Carlos Lopez JaramilloDepartment of Psychiatry, University of Antioquía, Medellín, Colombia.
Nelson B FreimerCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
A Latin American biobank for large-scale genetics research on severe mental illnessR01MH123157 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., LOPEZ JARAMILLO, CARLOS · 2020 to 2025
$10.6M
Genetics of Severe Mental IllnessR01MH113078 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, FREIMER, NELSON B. · 2017 to 2021
$5.8M
4/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African AncestriesU01MH125042 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., LOPEZ JARAMILLO, CARLOS · 2020 to 2024
$5.3M
The Impact of the COVID-19 Pandemic on Severe Mental IllnessRF1MH133426 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., LOPEZ JARAMILLO, CARLOS · 2023 to 2023
$3.1M
Genome Sequencing in Extended Bipolar PedigreesR01MH095454 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2012 to 2014
$2.4M
Accelerating the Diagnosis of Bipolar Disorder Using Genetic and Phenotypic SignaturesR00MH116115 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLDE LOOHUIS, LOES MARLEIN · 2020 to 2022
$747k
NCATS NIH HHS UL1 TR001881NIMH NIH HHS R00 MH116115NIMH NIH HHS R01 MH095454NIMH NIH HHS R01 MH113078NIMH NIH HHS R01 MH123157NIMH NIH HHS RF1 MH133426NIMH NIH HHS U01 MH125042
6 · The paper itself

Abstract

Most genome-wide association studies (GWAS) of serious mental illness (SMI) have been conducted for categorical diagnoses in samples of primarily European ancestry. The portability of findings to non-Europeans, and to SMI-related symptoms/dimensional traits remains uncertain. In a sample of 8,666 SMI cases and controls from the Paisa region of Colombia we show that a primarily European schizophrenia GWAS polygenic risk score (PRS) predicted all SMI diagnoses in this sample, as well as symptoms (assessed in cases only) and traits assessed agnostic to SMI diagnosis: a one SD unit (SDU) increase in this PRS was associated to decreased risk in cases of suicidal thoughts (OR=0.89, 95% confidence interval 0.84-0.94), depressed mood (OR=0.90, 95% confidence interval 0.85-0.95), and increased risk of delusions (OR=1.12, 95% confidence interval 1.06-1.18) and to decreased cognition (in cases and controls) across five distinct domains (average decrease in cognition of 0.065 SDU, p<7e-05). We show that a published European GWAS of cognition predicted levels of executive function (average decrease in cognition of 0.06 SDU per unit increase in PRS, p<2e-04), but not diagnosis or symptoms. Specific loci identified in the SMI GWAS also showed association to multiple diagnoses, symptoms, and cognitive traits in Paisa. The most noteworthy result was for a locus on chromosome 7p22.3, associated in multiple SMI GWAS, that showed association in Paisa to increased risk of bipolar disorder, and to reduced complex cognition and social cognition. Our findings demonstrate wide portability from European GWAS to an admixed American sample, with associations to multiple transdiagnostic phenotypes.

Identifiers

PMID42145589
PMCPMC13174737

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.