Evidence map›Paper›PMID 42145682›Full record

ArticleBiomedical optics express2026

Miniaturized handheld Raman imager based on 2D MEMS scanning for non-destructive analysis of thermally sensitive samples.

Yuhe Zheng, Taotao Mu

Abstract read
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuhe ZhengSchool of Instrumentation Science and Opto-electronics Engineering, Beijing Information Science and Technology University, Beijing 100192, China.ORCID https://orcid.org/0009-0002-8384-0728
Taotao MuSchool of Instrumentation Science and Opto-electronics Engineering, Beijing Information Science and Technology University, Beijing 100192, China.ORCID https://orcid.org/0009-0003-0561-1660

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-power-density laser focusing can enhance Raman throughput but often causes thermal degradation in dark or heat-sensitive samples, leading to fluorescence background, peak distortion, or even material combustion. Here, we present a handheld Raman imaging system incorporating a two-dimensional micro-electro-mechanical (2D MEMS) mirror that enables programmable spatial scanning of the excitation beam. By distributing laser energy temporally and spatially, the proposed system effectively suppresses photothermal damage while preserving spectral fidelity. Replacing conventional 2D nano-positioning stages with a MEMS scanning module enables, to the best of our knowledge, the first handheld Raman device capable of performing full-field (i.e., simultaneous imaging of the entire field of view) chemical imaging. Experiments on four dark or thermally sensitive substances, including potassium permanganate and Sudan III, demonstrate significant reductions in localized power density, improved signal-to-noise ratio (SNR), and complete elimination of sample damage. Point array scan imaging of a composite pharmaceutical tablet further visualizes the spatial distribution of its chemical components, confirming the system's practical utility for non-destructive, field-deployable Raman imaging. The integration of MEMS scanning technology addresses long-standing limitations of conventional Raman systems and aligns with the growing demand for miniaturized, portable optical sensors.

Identifiers

PMID42145682
PMCPMC13178589

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.