Kinetic Overview of Polynuclear Platinum(II) Complexes in Heparan Sulfate Substitution: Mimetic Model Analysis and Mechanistic Perspectives.

Frederico Henrique do C R Ferreira, Nicholas P Farrell, Luiz Antônio S Costa

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Frederico Henrique do C R FerreiraNEQC - Núcleo de Estudos em Química Computacional, Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, S/N, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.

Nicholas P FarrellDepartment of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284-2006, United States.ORCID https://orcid.org/0000-0001-7160-7182

Luiz Antônio S CostaNEQC - Núcleo de Estudos em Química Computacional, Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, S/N, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polynuclear platinum-(II) complexes (PPCs) represent a promising class of anticancer agents, offering enhanced efficacy and reduced toxicity compared with traditional mononuclear platinum drugs. Their interactions extend beyond DNA to include noncovalent and covalent binding with biologically relevant anions, such as sulfates and carboxylates, in glycosaminoglycans (GAGs) like heparan sulfate (HS) and chondroitin sulfate. This study investigates the chloride substitution mechanisms in PPCs using a Cl-PtN3 model, evaluating both aquation-driven and direct substitution pathways with GAG mimetic models of iduronic acid, IdoA-(2S), and glucose, GlcNS-(6S). A computational benchmarking analysis identified the double-hybrid DFT functional B2PLYP as the most accurate method, displaying an absolute deviation of only 1.05 kcal mol

Identifiers

PMID42146185

DOI10.1021/acsomega.5c13472

PMCPMC13176995

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.