Evidence map›Paper›PMID 42146417›Full record

ArticlebioRxiv : the preprint server for biology2026

An interaction between HP1 and the Chromosomal Passenger Complex Initiates Acentrosomal Spindle Assembly in

Siwen Wu, Ryan Doherty, Manisha Persaud, Keara Greer, Om Patil, Janet K Jang, Kim McKim

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siwen WuWaksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Ryan DohertyWaksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Manisha PersaudWaksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Keara GreerWaksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Om PatilWaksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Janet K JangWaksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.
Kim McKimWaksman Institute, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America.ORCID 0000-0002-8990-1168

Funding

Homolog orientation and segregation in acentrosomal meiosisR01GM101955 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI MCKIM, KIM S · 2013 to 2024
$4.6M
NIGMS NIH HHS R01 GM101955
6 · The paper itself

Abstract

Chromosome segregation fidelity during meiosis is critical for genome integrity, with aneuploidy causing infertility, miscarriages, and congenital anomalies. In the oocytes of many species, spindle assembly occurs in the absence of centrosomes that normally function as microtubule-organizing centers at the poles. Such acentrosomal spindles are believed to pose significant challenges for accurate chromosome segregation compared to centrosomal organized spindles. Previous work in

Indexed as

chromosome segregationDrosophilameiosisspindle assembly

Identifiers

PMID42146417
PMCPMC13174702

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.