ArticleFrontiers in endocrinology2026
Clinicopathological landscape and management trends of thyroid carcinoma over two decades: a single-institution study and risk stratification of central lymph node metastasis in T1 papillary thyroid carcinoma.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to describe the clinicopathological landscape of thyroid disease, summarize long-term management trends of thyroid carcinoma (TC) and lymph node metastasis (LNM) from 1999 to 2018, and develop a nomogram to predict central lymph node metastasis (CLNM) in patients with T1-stage papillary thyroid carcinoma (PTC). Methods: A total of 34,420 patients with thyroid disease were included for landscape analysis, among whom 18,917 patients with TC were analyzed for management trends. Subsequently, 11,760 patients with T1-stage PTC were enrolled to identify risk factors for CLNM. A predictive nomogram was constructed using multivariable logistic regression and internally validated. Results: Among all patients, 22,919 were diagnosed with thyroid cancer and 11,501 with benign nodules. The proportion of TC increased steadily, reaching 99.3% in 2018. PTC accounted for 99.3% of TC cases, while the proportion of papillary thyroid microcarcinoma showed a slight decline. The rate of central lymph node dissection increased from 34.4% to 97%, whereas the CLNM rate decreased from 81.8% to 55%. In contrast, lateral lymph node dissection declined from 58.3% to 28.8%, with a corresponding reduction in lateral lymph node metastasis. Younger age, male sex, larger maximum tumor diameter (MTD), multifocality, lymphovascular invasion, and capsule invasion were identified as independent risk factors for CLNM (all p<0.05). The optimal MTD cutoff was 0.75 cm. The nomogram showed good discrimination (C-index 0.715) and satisfactory calibration. Conclusions: This study demonstrates evolving patterns and increasing standardization in thyroid cancer management over two decades. The proposed nomogram may serve as a postoperative pathology-based risk stratification tool to support individualized management and follow-up in patients with T1-stage PTC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.