Evidence map›Paper›PMID 42147117›Full record

ArticleFrontiers in endocrinology2026

Case Report: rapid progressive puberty in siblings with

Hui Huang, Yu Yang, Xiangyu Xiong, Dongguang Zhang, Li Yang, Liling Xie

Abstract readCase Reports
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hui HuangJiangxi Provincial Key Laboratory of Child Development and Genetics, Jiangxi Provincial Children's Hospital (The Affiliated Children's Hospital of Nanchang Medical College), Nanchang, China.
Yu YangJiangxi Provincial Key Laboratory of Child Development and Genetics, Jiangxi Provincial Children's Hospital (The Affiliated Children's Hospital of Nanchang Medical College), Nanchang, China.
Xiangyu XiongDepartment of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital (The Affiliated Children's Hospital of Nanchang Medical College), Nanchang, China.
Dongguang ZhangDepartment of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital (The Affiliated Children's Hospital of Nanchang Medical College), Nanchang, China.
Li YangDepartment of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital (The Affiliated Children's Hospital of Nanchang Medical College), Nanchang, China.
Liling XieDepartment of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital (The Affiliated Children's Hospital of Nanchang Medical College), Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pathogenic variants in melanocortin-4 receptor ( Case report: We report two Chinese siblings with severe early-onset obesity and accelerated pubertal tempo. Trio-based whole-exome sequencing with segregation analysis identified a heterozygous Conclusion: Longitudinal follow-up of siblings carrying the pathogenic

Indexed as

Gonadotropin-Releasing HormoneObesityPubertyPuberty, PrecociousReceptor, Melanocortin, Type 4AdolescentChildFemaleFollow-Up StudiesHumansLongitudinal StudiesPuberty InhibitorsPuberty SuppressionSiblingsGonadotropin-Releasing HormoneMC4R protein, humanPuberty InhibitorsReceptor, Melanocortin, Type 4GnRH agonistinsulin resistancelifestyle interventionMC4Rmonogenic obesityrapidly progressive puberty

Identifiers

PMID42147117
PMCPMC13175789

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.