ArticleResearch square2026
Utilizing maternal autoantibody patterns to predict risk of autism and intellectual disability in offspring.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
8 authors.
Funding
Abstract
Maternal autoantibody-related autism (MARA) is a subset of autism in which specific patterns of maternal autoantibodies (aABs) in the circulation of pregnant women have been associated with increased autism risk in offspring. While initial MARA studies identified patterns consisting of two maternal aABs that predicted increased risk of autism, other multi-aAB patterns predictive of autism and other neurodevelopmental disorders have not yet been fully assessed. In this study, we aimed to determine if additional patterns of MARA aABs can be used to predict the risk of autism and intellectual disability (ID). We tested maternal plasma samples from the Early Markers for Autism (EMA) study for reactivity to eight proteins with clinical relevance in our initial MARA studies. Least Absolute Shrinkage and Selection Operator (LASSO) statistical modeling was used to identify patterns of three maternal aABs that were predictive of offspring autism and ID risk. We identified novel patterns consisting of three aABs associated with increased risk of autism or ID compared to general population controls (GP). Additionally, we found that specific patterns of three maternal aABs differentially predicted risk of autism with intellectual disability (AU ID) and autism without intellectual disability (AU noID), compared to GP. Overall, novel patterns consisting of three maternal aABs have been identified and can be used to predict child clinical risk of autism, ID, and autism subgroups, AU ID and AU noID.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.