Evidence map›Paper›PMID 42147187›Full record

ArticleResearch square2026

Gut microbial interaction networks control autoimmunity to neuroretina.

Amy Zhang, Reiko Horai, Yingyos Jittayasothorn, Jonathan H Badger, Zhichao Wu, Guangpu Shi, Akriti Gupta, Samyuktha Arunkumar, Caitlin E Murphy, Vijayaraj Nagarajan and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Amy ZhangLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Reiko HoraiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Yingyos JittayasothornLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Jonathan H BadgerGenetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-5662-423X
Zhichao WuLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Guangpu ShiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Akriti GuptaLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Samyuktha ArunkumarLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Caitlin E MurphyLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Vijayaraj NagarajanLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
John A McCullochGenetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Shilpa KodatiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
H Nida SenLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Jung Wha LeeLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Jonathan P JacobsGoodman-Luskin Microbiome Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-4698-0254
Xiaoyan XuLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Mary J MattapallilLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-0615-7343
Zixuan PengLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Biying XuLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Robert J PalmerStructural Biochemistry Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Nadim MajdalaniLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-9314-5203
Kenya HondaKeio University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8937-9835
Colm O'hUiginGenetics and Microbiome Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Rachel R CaspiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-7140-7671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome influences the development of immune-mediated inflammatory diseases, including autoimmune uveitis, a sight-threatening ocular inflammation driven by retina-specific T cells

Indexed as

AkkermansiaAutoimmune uveitisGut microbiomehuman floraShort-chain fatty acidsTh1 effector response

Identifiers

PMID42147187
PMCPMC13174817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.