Evidence mapPaperPMID 42147192Full record

ArticleResearch square2026

Plasma proteomics link menopause timing to brain aging and dementia risk.

Madeline Wood Alexander, Brendan Wood, Hamilton See-Hwee Oh, Veronica Augustina Bot, Julia Borger, Francesca Galbiati, Keenan A Walker, Susan M Resnick, Heather M Ochs-Balcom, Tony Wyss-Coray and 6 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Madeline Wood AlexanderHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0003-4598-0201
Brendan WoodHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Hamilton See-Hwee OhNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8192-7593
Veronica Augustina BotThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.ORCID 0009-0008-5060-1142
Julia BorgerEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Francesca GalbiatiCalifornia Center for Pituitary Disorders, University of California, San Francisco, California, USA.ORCID 0000-0003-0744-2541
Keenan A WalkerLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, US.ORCID 0000-0002-5989-9853
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, US.ORCID 0000-0003-1115-7145
Heather M Ochs-BalcomDepartment of Epidemiology and Environmental Health, State University of New York at Buffalo, NY, USA.
Tony Wyss-CorayThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5893-0831
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1427-4470
Emily G JacobsDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, California, USA.ORCID 0000-0003-0001-5096
Jennifer S RabinHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0003-4754-2221
Kaitlin B CasalettoEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Rowan SalonerEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID 0000-0002-1351-6183

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier menopause is a risk factor for several age-related diseases, including dementia. The biological pathways linking menopause timing to later-life brain aging are not understood. Leveraging large-scale plasma proteomics in postmenopausal women from the UK Biobank (

Identifiers

PMID42147192
PMCPMC13174772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.