ArticleResearch square2026
A deformylase inhibitor expands therapeutic options for Lyme disease.
Kim Lewis, Pankaj Patil, Hsin-Wen Liang, Eleanor Astley, Raleb Taher, Mi-Hyun Lee, Daniel Norment, Akira Iinishi, Nikita Gupta, Katerina Sobolevskaia and 9 more
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Pankaj PatilNortheastern university.
Hsin-Wen LiangNortheastern university.
Eleanor AstleyTufts university.
Raleb TaherNortheastern university.
Mi-Hyun LeeNortheastern university.
Daniel NormentNortheastern university.
Akira IinishiAntimicrobial Discovery Center, Department of Biology, Northeastern University.
Nikita GuptaNortheastern university.
Katerina SobolevskaiaNortheastern university.
Eric ChenTufts university.
Akbar NawabUniversity of North Dakota.
Justice AdzreUniversity of North Dakota.
Bryson HawkinsUniversity of New South Wales.
Jeffrey BourgeoisWorcester Polytechnic Institute.
Melissa CaimanoUniversity of Connecticut Health Center.
Linden HuTufts Medicine.
Funding
RpoS Regulation of Borrelia burgdorferi Genes in vivoR01AI029735 · NIAID · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI CAIMANO, MELISSA J, RADOLF, JUSTIN D · 1990 to 2022
$10.7MDevelopment and Field Testing of a Novel Reservoir Targeted Antibiotic Against Borrelia burgdorferiR01AI152210 · NIAID · TUFTS UNIVERSITY BOSTON · PI HU, LINDEN T, LEWIS, KIM · 2020 to 2025
$3.9MDeciphering Borrelia burgdorferi RpoS regulatory networks in ticks and mammalsR01AI192838 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MELISSA J CAIMANO, Justin D Radolf · 2025 to 2026
$1.4MContribution of RpoS to persistence of Borrelia burgdorferi in mammalsR21AI187932 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAIMANO, MELISSA J, RADOLF, JUSTIN D · 2025 to 2025
$458kNutrient acquisition and cyclic nucleotide signaling in Treponema pallidum as underpinnings of stealth pathogenicityR21AI194255 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAIMANO, MELISSA J, RADOLF, JUSTIN D · 2025 to 2025
$458kElucidating the contributions of c-di-GMP and PlzA to tick- and mammalian host-adaptation in Lyme disease spirochetesR21AI173921 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAIMANO, MELISSA J · 2023 to 2024
$457kNIAID NIH HHS R01 AI029735NIAID NIH HHS R01 AI152210NIAID NIH HHS R01 AI192838NIAID NIH HHS R21 AI173921NIAID NIH HHS R21 AI187932NIAID NIH HHS R21 AI194255
6 · The paper itselfAbstract
Lyme disease incidence continues to rise globally. This vector-borne infection remains a major public health burden. Broad-spectrum doxycycline and ceftriaxone disrupt the gut microbiome, drive resistance in commensals, and offer suboptimal efficacy against neuroborreliosis. Here we show that forazemin, previously known as BB-83698, is an orally bioavailable peptide deformylase inhibitor with potent and selective bactericidal activity against spirochaetes, including diverse
Identifiers
PMID42147198
PMCPMC13174789
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390