Evidence mapPaperPMID 42147199Full record

ArticleResearch square2026

Nicotine protects astrocytes expressing alpha-synuclein against aminochrome cytotoxicity: Implications for Parkinson's disease.

Érica Novaes Soares, Cynthia Silva Bartolomeo, Tiago Nicoliche, Irlã Santos Lima, Lucas Matheus Gonçalves de Oliveira, Gabriel de Jesus Ferrolho, Rafaela Brito Oliveira, Roberta Sessa Stilhano, Silvia Lima Costa, Yousef Tizabi and 2 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Érica Novaes SoaresFederal University of Bahia.
Cynthia Silva BartolomeoFaculty of Medical Sciences of Santa Casa de São Paulo, , Brazil.
Tiago NicolicheFaculty of Medical Sciences of Santa Casa de São Paulo, , Brazil.
Irlã Santos LimaFederal University of Bahia.
Lucas Matheus Gonçalves de OliveiraFederal University of Bahia.
Gabriel de Jesus FerrolhoFederal University of Bahia.
Rafaela Brito OliveiraFederal University of São Paulo.
Roberta Sessa StilhanoFaculty of Medical Sciences of Santa Casa de São Paulo, , Brazil.
Silvia Lima CostaFederal University of Bahia.
Yousef TizabiHoward University College of Medicine.
Rodrigo Portes UreshinoFederal University of São Paulo.
Victor Diogenes Amaral da SilvaFederal University of Bahia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocytes containing alpha-synuclein (α-Syn) are a cytopathological finding in

Indexed as

alpha-synucleinaminochromeastrocytesneuroprotectionnicotineParkinson’s disease

Identifiers

PMID42147199
PMCPMC13174781

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.